Hippuristanol-A potent steroid inhibitor of eukaryotic initiation factor 4A
R Cencic, J Pelletier - Translation, 2016 - Taylor & Francis
Protein synthesis and its regulatory signaling pathways play essential roles in the initiation
and maintenance of the cancer phenotype. Insight obtained over the last 3 decades on the …
and maintenance of the cancer phenotype. Insight obtained over the last 3 decades on the …
Targeting the eIF4A RNA helicase as an anti-neoplastic approach
J Chu, J Pelletier - Biochimica et Biophysica Acta (BBA)-Gene Regulatory …, 2015 - Elsevier
Protein synthesis is an essential cellular process that is highly responsive to extra-and
intracellular cues such as mitogens, growth signals, nutrient and energy status, and stress …
intracellular cues such as mitogens, growth signals, nutrient and energy status, and stress …
Chemical synthesis of the cardiotonic steroid glycosides and related natural products
B Heasley - Chemistry–A European Journal, 2012 - Wiley Online Library
The active components from the extracts of Digitalis, cardiotonic steroid glycosides, have
been ingested by humans for more than 200 years as a medicinal therapy for heart failure …
been ingested by humans for more than 200 years as a medicinal therapy for heart failure …
Selective targeting of the DEAD-box RNA helicase eukaryotic initiation factor (eIF) 4A by natural products
L Shen, J Pelletier - Natural product reports, 2020 - pubs.rsc.org
Covering: up to 2019 Pharmacological targeting of eukaryotic mRNA translation initiation is
a promising approach for cancer therapy, since several signaling pathways that are …
a promising approach for cancer therapy, since several signaling pathways that are …
Strategies for spiroketal synthesis based on transition-metal catalysis
JA Palmes, A Aponick - Synthesis, 2012 - thieme-connect.com
The transition-metal-catalyzed synthesis of spiroketals is a rapidly growing area and these
methods have facilitated the use of new spiroketal synthons as latent spiroketal equivalents …
methods have facilitated the use of new spiroketal synthons as latent spiroketal equivalents …
Modifying chemotherapy response by targeted inhibition of eukaryotic initiation factor 4A
Translation is regulated predominantly at the initiation phase by several signal transduction
pathways that are often usurped in human cancers, including the PI3K/Akt/mTOR axis …
pathways that are often usurped in human cancers, including the PI3K/Akt/mTOR axis …
Emerging therapeutics targeting mRNA translation
A Malina, JR Mills, J Pelletier - Cold Spring Harbor …, 2012 - cshperspectives.cshlp.org
A defining feature of many cancers is deregulated translational control. Typically, this occurs
at the level of recruitment of the 40S ribosomes to the 5′-cap of cellular messenger RNAs …
at the level of recruitment of the 40S ribosomes to the 5′-cap of cellular messenger RNAs …
RNA-tethering assay and eIF4G: eIF4A obligate dimer design uncovers multiple eIF4F functional complexes
Eukaryotic cellular mRNAs possess a 5′ cap structure (m7GpppN) which plays a critical
role in translation initiation mediated by eukaryotic initiation factor (eIF) 4F. The …
role in translation initiation mediated by eukaryotic initiation factor (eIF) 4F. The …
Total synthesis of Beshanzuenone D and its epimers and Abiespiroside A
A unified and protecting-group-free six-step total synthesis of bisabolane-type
sesquiterpenoid beshanzuenone D and its stereoisomers and abiespiroside A using S-(+) …
sesquiterpenoid beshanzuenone D and its stereoisomers and abiespiroside A using S-(+) …
Lewis acid catalyzed cascade annulation of alkynols with α-ketoesters: a facile access to γ-spiroketal-γ-lactones
DA Kambale, SS Thorat, MS Pratapure… - Chemical …, 2017 - pubs.rsc.org
A novel Lewis acid catalyzed intermolecular cascade annulation of alkynols with α-
ketoesters has been developed. This simple and efficient cascade annulation proceeds …
ketoesters has been developed. This simple and efficient cascade annulation proceeds …