Since the discovery of Stimulator of Interferon Genes (STING) as an important pivot for
cytosolic DNA sensation and interferon (IFN) induction, intensive efforts have been …

Protein posttranslational modifications (PTMs) refer to the breaking or generation of covalent
bonds on the backbones or amino acid side chains of proteins and expand the diversity of …

Stimulator of interferon genes (STING) is an endoplasmic-reticulum resident protein, playing
essential roles in immune responses against microbial infections. However, over-activation …

The plasma membrane proteome is a rich resource of functionally important and
therapeutically relevant protein targets. Distinguished by high hydrophobicity, heavy …

Redox post‐translational modifications on cysteine thiols (redox PTMs) have profound
effects on protein structure and function, thus enabling regulation of various biological …

Stimulator of interferon genes (STING) is a core DNA sensing adaptor in innate immune
signaling. STING activity is regulated by a variety of post‐translational modifications (PTMs) …

Background The majority of colorectal carcinomas (CRCs) are insensitive to programmed
death protein-1/programmed death-ligand 1 (anti-PD-1/PD-L1) immune checkpoint inhibitor …

As antibiotic-resistant bacteria continue to emerge frequently, bacterial infections have
become a significant and pressing challenge to global public health. Innate immunity …

Cysteine oxidations play important regulatory roles during animal virus infections. Despite
the importance of redox modifications during plant infections, no plant virus protein has yet …

Protein disulfide isomerases (PDIs) catalyze redox reactions that reduce, oxidize, or
isomerize disulfide bonds and act as chaperones of proteins as they fold. The characteristic …