Both obesity and aging are associated with the development of metabolic diseases such as
type 2 diabetes and cardiovascular disease. Chronic low-grade inflammation of adipose …

Aging is characterized by a morpho-functional adaptation, variably affecting major
physiological systems, depending on a complex interaction between genetic, environmental …

The human ageing process is universal, ubiquitous and inevitable. Every physiological
function is being continuously diminished. There is a range between two distinct phenotypes …

During the last 40 years, there has been a world-wide increase in both the prevalence of
obesity and an increase in the number of persons over the age of 60 due to a decline in …

Ageing, like obesity, is often associated with alterations in metabolic and inflammatory
processes resulting in morbidity from diseases characterised by poor metabolic control …

Aging-related illnesses are increasing and effective strategies to prevent and/or treat them
are lacking. This is because of a poor understanding of therapeutic targets. Low-grade …

The FOXM1 transcription factor exhibits pleiotropic C-terminal transcriptional and N-terminal
non-transcriptional functions in various biological processes critical for cellular homeostasis …

The interplay between adipose tissue and skeletal muscle and the impact on mobility and
aging remain enigmatic. The progressive decline in mobility promoted by aging has been …

Among all major organs, the brain is one of the most susceptible to the inexorable effects of
aging. Throughout the last decades, several studies in human cohorts and animal models …

Aim Over the last decades, the shift in age distribution towards older ages and the
progressive ageing which has occurred in most populations have been paralleled by a …