It has long been recognized that an increase of reactive oxygen species (ROS) can modify
the cell‐signaling proteins and have functional consequences, which successively mediate …

Disrupted redox status primarily contributes to myocardial ischemia/reperfusion injury (MIRI).
NRF2, the endogenous antioxidant regulator, might provide therapeutic benefits …

Reactive oxygen species (ROS) are well known to be involved in oncogene-mediated
cellular transformation. However, the regulatory mechanisms underlying ROS generation in …

Intracellular pathogens mobilize host signaling pathways of their host cell to promote their
own survival. Evidence is emerging that signal transduction elements are activated in a …

The hypothalamus plays a fundamental role in controlling lipid metabolism through
neuroendocrine signals. However, there are currently no available drug targets in the …

The application of a targeted mass spectrometric workflow to the sensitive identification of
post-translational modifications is described. This protocol employs multiple reaction …

Active epidermal growth factor receptors (EGFR) signaling mediates the progression of
colorectal cancer (CRC) through activation of downstream kinases and transcription factors …

We previously demonstrated that protein kinase Cδ (PKCδ; PKC delta) is an oxidative stress-
sensitive kinase that plays a causal role in apoptotic cell death in neuronal cells. Although …

Protein kinase C delta (PKCδ) is a Ser/Thr-specific kinase involved in many fundamental
cellular processes including growth, differentiation and apoptosis. PKCδ is expressed …

Glioblastoma is an aggressive malignant brain tumor that starts in the brain or spine and
frequently recurs after anticancer treatment. The development of an accurate diagnostic …