Structure, function, and pharmacology of glutamate receptor ion channels
Many physiologic effects of l-glutamate, the major excitatory neurotransmitter in the
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …
Structural and functional architecture of AMPA-type glutamate receptors and their auxiliary proteins
IH Greger, JF Watson, SG Cull-Candy - Neuron, 2017 - cell.com
AMPA receptors (AMPARs) are tetrameric ion channels that together with other ionotropic
glutamate receptors (iGluRs), the NMDA and kainate receptors, mediate a majority of …
glutamate receptors (iGluRs), the NMDA and kainate receptors, mediate a majority of …
Structural mobility tunes signalling of the GluA1 AMPA glutamate receptor
AMPA glutamate receptors (AMPARs), the primary mediators of excitatory
neurotransmission in the brain, are either GluA2 subunit-containing and thus Ca2+ …
neurotransmission in the brain, are either GluA2 subunit-containing and thus Ca2+ …
[HTML][HTML] AMPA receptor trafficking and LTP: Carboxy-termini, amino-termini and TARPs
J Díaz-Alonso, RA Nicoll - Neuropharmacology, 2021 - Elsevier
AMPA receptors (AMPARs) are fundamental elements in excitatory synaptic transmission
and synaptic plasticity in the CNS. Long term potentiation (LTP), a form of synaptic plasticity …
and synaptic plasticity in the CNS. Long term potentiation (LTP), a form of synaptic plasticity …
Subsynaptic positioning of AMPARs by LRRTM2 controls synaptic strength
Recent evidence suggests that nano-organization of proteins within synapses may control
the strength of communication between neurons in the brain. The unique subsynaptic …
the strength of communication between neurons in the brain. The unique subsynaptic …
AMPA receptor structure and auxiliary subunits
A Kamalova, T Nakagawa - The Journal of physiology, 2021 - Wiley Online Library
Fast excitatory synaptic transmission in the mammalian brain is largely mediated by AMPA‐
type ionotropic glutamate receptors (AMPARs), which are activated by the neurotransmitter …
type ionotropic glutamate receptors (AMPARs), which are activated by the neurotransmitter …
Phosphorylation-Dependent Regulation of Ca2+-Permeable AMPA Receptors During Hippocampal Synaptic Plasticity
AM Purkey, ML Dell'Acqua - Frontiers in synaptic neuroscience, 2020 - frontiersin.org
Experience-dependent learning and memory require multiple forms of plasticity at
hippocampal and cortical synapses that are regulated by N-methyl-D-aspartate receptors …
hippocampal and cortical synapses that are regulated by N-methyl-D-aspartate receptors …
Neuroligin-3 confines AMPA receptors into nanoclusters, thereby controlling synaptic strength at the calyx of Held synapses
The subsynaptic organization of postsynaptic neurotransmitter receptors into nanoclusters
that are aligned with presynaptic release sites is essential for the high fidelity of synaptic …
that are aligned with presynaptic release sites is essential for the high fidelity of synaptic …
Structural mechanisms of gating in ionotropic glutamate receptors
EC Twomey, AI Sobolevsky - Biochemistry, 2018 - ACS Publications
Ionotropic glutamate receptors (iGluRs) are ligand-gated ion channels that mediate the
majority of excitatory neurotransmission in the central nervous system. iGluRs open their ion …
majority of excitatory neurotransmission in the central nervous system. iGluRs open their ion …
Positive AMPA receptor modulation in the treatment of neuropsychiatric disorders: A long and winding road
Glutamatergic transmission is widely implicated in neuropsychiatric disorders, and the
discovery that ketamine elicits rapid-acting antidepressant effects by modulating α-amino-3 …
discovery that ketamine elicits rapid-acting antidepressant effects by modulating α-amino-3 …