Since the first antiviral drug, idoxuridine, was approved in 1963, 90 antiviral drugs
categorized into 13 functional groups have been formally approved for the treatment of the …

Tissues are the new frontier of discoveries in immunology. Cells of the immune system are
an integral part of tissue physiology and immunity. Determining how immune cells inhabit …

The cerebral cortex is a complex structure that contains different classes of neurons
distributed within six layers and regionally organized into highly specialized areas. Cortical …

During pregnancy, the placenta forms the anatomical barrier between the mother and
developing fetus. Infectious agents can potentially breach the placental barrier resulting in …

Human cytomegalovirus (HCMV) is a highly prevalent herpesvirus that can cause severe
disease in immunocompromised individuals and immunologically immature fetuses and …

Human Cytomegalovirus (hCMV), which is the prototype member of the β-subfamily of the
herpesvirus family, is a pathogen of high clinical relevance in recipients of hematopoietic …

Since murine cytomegalovirus (MCMV) was first described in 1954, it has been used to
model human cytomegalovirus (HCMV) diseases. MCMV is a natural pathogen of mice that …

Viral infections remain a global public health concern and cause a severe societal and
economic burden. At the organismal level, the innate immune system is essential for the …

Immunological memory is a cardinal feature of adaptive immunity. Although natural killer
(NK) cells have long been considered short-lived innate lymphocytes that respond rapidly to …

Human cytomegalovirus (HCMV) causes congenital neurological lifelong disabilities. To
date, the neuropathogenesis of brain injury related to congenital HCMV (cCMV) infection is …