Helper T (Th) cell subsets direct immune responses by producing signature cytokines. Th2
cells produce IL-4, IL-5, and IL-13, which are important in humoral immunity and protection …

The zinc-finger transcription factor GATA-3 has received much attention as a master
regulator of T helper 2 (Th2) cell differentiation, during which it controls interleukin-4 (IL-4) …

Tregs not only keep immune responses to autoantigens in check, but also restrain those
directed toward pathogens and the commensal microbiota. Control of peripheral immune …

Background Inborn errors of immunity have been implicated in causing immune
dysregulation, including allergic diseases. STAT6 is a key regulator of allergic responses …

GATA3 has conventionally been regarded as a transcription factor that drives the
differentiation of T helper (Th) 2 cells. Increasing evidence points to a function for GATA3 …

Th2 cells play a key role in directing immune responses against helminths. Additionally, Th2
cells are crucial for many types of allergic reactions. Whereas the molecular mechanisms …

Innate lymphoid cells (ILCs) and adaptive T lymphocytes promote tissue homeostasis and
protective immune responses. Their production depends on the transcription factor GATA3 …

Dendritic cells (DCs) are the professional antigen-presenting cells that recognize and
present antigens to naïve T cells to induce antigen-specific adaptive immunity. Among the T …

Long non-coding RNAs (lncRNAs) possess a diverse array of regulatory functions including
activation and silencing of gene transcription, regulation of splicing, and coordinating …

IL-33, a member of the IL-1 family of cytokines, was originally described in 2005 as a
promoter of type 2 immune responses. However, recent evidence reveals a more complex …