Catalytic enantioselective transformations provide well-established and direct access to
stereogenic synthons that are broadly distributed among active pharmaceutical ingredients …

Recent years have witnessed an explosive growth in the field of amino organocatalysis,
especially in asymmetric enamine and iminium catalysis. Except for the obvious interaction …

The two-step flow asymmetric synthesis of chiral γ-nitrobutyric acids as key intermediates of
the GABA analogues baclofen, phenibut, and fluorophenibut is reported on a multigram …

The immobilization of the catalyst on a support with the aim of facilitating the separation of
the product from the catalyst, and thus the recovery and recycling of the latter, can be …

Polymer-supported chiral organocatalysts, as well as most other forms of immobilized
catalysts, are traditionally prepared by a postmodification approach where modified catalyst …

In this microreview, we highlight the field of polymer‐supported organocatalysis, especially
immobilized enamine and iminium organocatalysts. We try to formalize the overall synthetic …

The enzyme 4-oxalocrotonate tautomerase (4-OT) exploits an N-terminal proline as main
catalytic residue to facilitate several promiscuous C–C bond-forming reactions via enzyme …

The catalytic enantioselective synthesis of the chiral key intermediate of the antidepressant
(−)-paroxetine is demonstrated as a continuous flow process on multi-gram scale. The …

Sustainability concerns are the wind in the sails for the development of novel, more selective
catalytic processes. Hence, chiral catalysts play a crucial role in the green production of …

The Michael-type addition reaction is widely used in organic synthesis for carbon–carbon
bond formation. However, biocatalytic methodologies for this type of reaction are scarce …