Since its clinical introduction in 1998, the topoisomerase I inhibitor irinotecan has been
widely used in the treatment of solid tumors, including colorectal, pancreatic, and lung …

There is a significant interest in identifying blood-borne factors that mediate tissue crosstalk
and function as molecular effectors of physical activity. Although past studies have focused …

Here, we reported the production of hyaluronic acid/polyaspartamide-based double-network
nanogels for the potential treatment of colorectal carcinoma. Graphene oxide, thanks to the …

Background and objective Side effects of irinotecan treatment can be dose limiting and may
impair quality of life. In this study, we investigated the correlation between single nucleotide …

ABSTRACT Topoisomerase 1 (TOPO-1) and carboxylesterase 2 (CES-2) are found to play
crucial roles in the pathogenesis of various cancers. The prognostic role of TOPO-1 and …

Central nervous system tumors have resisted effective chemotherapy because most
therapeutics do not penetrate the blood-tumor-brain-barrier. Nanomedicines between~ 10 …

PFASs are highly persistent in both natural and living environment, and pose a significant
risk for wildlife and human beings. The present study was carried out to determine the …

Purpose Current treatment options for head and neck squamous cell carcinoma (HNSCC)
are limited, especially for cases with cancer stem cell-induced chemoresistance and …

Abstract DDAB (6, 8-dichloro-9, 9-dimethyl-7-oxo-7, 9-dihydroacridin-2-yl benzoate) is a
newly developed near-infrared fluorescent probe for human carboxylesterase 2 (hCE2) …

Small cell neuroendocrine carcinoma (SCNEC) of the uterine cervix is a rare disease with a
poor prognosis. The lack of established disease models has hampered therapy …