Application of stimuli-responsive hydrogel in brain disease treatment

B Xie, H Xie - Frontiers in Bioengineering and Biotechnology, 2024 - frontiersin.org
Treating brain diseases presents significant challenges due to neuronal degeneration,
inflammation, and the intricate nature of the brain. Stimuli-responsive hydrogels, designed to …

[HTML][HTML] Nanomedicine in Neuroprotection, Neuroregeneration, and Blood–Brain Barrier Modulation: A Narrative Review

A Krsek, A Jagodic, L Baticic - Medicina, 2024 - mdpi.com
Nanomedicine is a newer, promising approach to promote neuroprotection,
neuroregeneration, and modulation of the blood–brain barrier. This review includes the …

Carboxymethyl chitosan and gelatin hydrogel scaffolds incorporated with conductive PEDOT nanoparticles for improved neural stem cell proliferation and neuronal …

S Guan, Y Wang, F Xie, S Wang, W Xu, J Xu, C Sun - Molecules, 2022 - mdpi.com
Tissue engineering scaffolds provide biological and physiochemical cures to guide tissue
recovery, and electrical signals through the electroactive materials possess tremendous …

Genipin-crosslinked, proteosaccharide scaffolds for potential neural tissue engineering applications

H Cassimjee, P Kumar, P Ubanako, YE Choonara - Pharmaceutics, 2022 - mdpi.com
Traumatic brain injuries (TBIs) are still a challenge for the field of modern medicine. Many
treatment options such as autologous grafts and stem cells show limited promise for the …

Exosomal microRNAs have great potential in the neurorestorative therapy for traumatic brain injury

Y Yang, H Yang, Y Yang, Y Ma - Experimental Neurology, 2022 - Elsevier
Traumatic brain injury (TBI) is a leading cause of brain impairment, resulting in acute neural
impairment and chronic long-term disability worldwide. Until now, no therapeutics …

A Gelatin Methacrylate-Based Hydrogel as a Potential Bioink for 3D Bioprinting and Neuronal Differentiation

EM Cruz, LS Machado, LN Zamproni, LV Bim… - Pharmaceutics, 2023 - mdpi.com
Neuronal loss is the ultimate pathophysiologic event in central nervous system (CNS)
diseases and replacing these neurons is one of the most significant challenges in …

Emerging scaffold-and cellular-based strategies for brain tissue regeneration and imaging

MN Collins, F Zamboni, A Serafin, A Escobar… - In vitro models, 2022 - Springer
Stimulating brain tissue regeneration is a major challenge after central nervous system
(CNS) injury, such as those observed from trauma or cerebrovascular accidents. Full …

Poly(N-acryloylglycine-acrylamide) Hydrogel Mimics the Cellular Microenvironment and Promotes Neurite Growth with Protection from Oxidative Stress

K Wasnik, PS Gupta, S Mukherjee, A Oviya… - ACS Applied Bio …, 2023 - ACS Publications
In this work, the glycine-based acryloyl monomer is polymerized to obtain a neurogenic
polymeric hydrogel for regenerative applications. The synthesized poly (N-acryloylglycine …

Biomaterial and tissue-engineering strategies for the treatment of brain neurodegeneration

B Martinez, PV Peplow - Neural Regeneration Research, 2022 - journals.lww.com
The incidence of neurodegenerative diseases is increasing due to changing age
demographics and the incidence of sports-related traumatic brain injury is tending to …

Toward a New Generation of Bio-Scaffolds for Neural Tissue Engineering: Challenges and Perspectives

F Villanueva-Flores, I Garcia-Atutxa, A Santos… - Pharmaceutics, 2023 - mdpi.com
Neural tissue engineering presents a compelling technological breakthrough in restoring
brain function, holding immense promise. However, the quest to develop implantable …