This review is a Part II of the series aiming to provide comprehensive overview of currently
used antiviral drugs and to show modern approaches to their analysis. While in the Part I …

A reversed-phase high-performance liquid chromatographic method was developed for the
simultaneous determination of sofosbuvir and ledipasvir in tablet dosage form. The analysis …

The recent epidemic of Zika virus (ZIKV) in the Americas and its association with fetal and
neurological complications has shown the need to develop a treatment. Repurposing of …

Specific, accurate, simple, selective and stability-indicating RP-HPLC method is developed
and validated for simultaneous determination of Sofosbuvir and Ledipasvir in tablet dosage …

The ProTide prodrug design is a powerful tool to improve cell permeability and enhance the
intracellular activation of nucleotide antiviral analogues. Previous in vitro studies showed …

Sofosbuvir and ribavirin exert their anti-hepatitis C virus (anti-HCV) activity following
metabolic activation in the liver. However, intrahepatic concentrations of the …

A smooth, exceptionally sensitive, correct, and extra reproducible RP-HPLC technique was
developed and demonstrated to estimate Sofosbuvir (SOF) in pharmaceutical dosage …

Although for many analyses tandem mass spectrometry (LC–MS/MS) systems have
significant advantage over the high-performance liquid chromatography with diode array …

We assessed factors that determine the tissue-specific bioactivation of ProTide prodrugs by
comparing the disposition and activation of remdesivir (RDV), its methylpropyl and isopropyl …

Sofosbuvir (SOFO) was approved by the US Food and Drug Administration in 2013 for the
treatment of hepatitis C virus infection with enhanced antiviral potency compared with earlier …