Genetic studies of hereditary forms of nephrotic syndrome have identified several proteins
that are involved in regulating the permselective properties of the glomerular filtration …

The Rho family of small GTPases (Rho GTPases) are the master regulators of the actin
cytoskeleton and consist of 22 members. Previous studies implicated dysregulation of Rho …

Regulation of the connection between the slit diaphragm and the podocyte actin network
requires complex interplay between multiple signaling pathways. New discoveries …

Objective. Spontaneous intracerebral hemorrhage (ICH) is a blood clot arising in the brain
parenchyma in the absence of trauma or surgery and accounts for 10% to 15% of all strokes …

Nephrotic syndrome is a kidney disease featured by heavy proteinuria. It is caused by injury
to the specialized epithelial cells called “podocytes” within the filtration unit of the kidney …

During the past several decades, resistance to single or multiple anticancer agents has
posed a great challenge in cancer therapy. Dedicator of cytokinesis 1 (DOCK1), the first …

The treatment of renal cell carcinoma (RCC) with chemotherapy remains a challenge;
therefore, improving the knowledge of the molecular mechanisms underlying RCC …

Background: Proteinuria is a cardinal sign of chronic kidney disease, which is a major
healthcare problem that affects millions of people worldwide. Recent advances in molecular …

Nephrotic syndrome (NS) is characterized by heavy proteinuria, hypoalbuminemia, and
edema. The underlying causes of NS are diverse and are tied to inheritable and …

Focal segmental glomerulosclerosis (FSGS) is a histopathological lesion characterized by
podocyte injury, during which the podocyte's actin-rich projections, called foot processes …