Metabolic syndrome: updates on pathophysiology and management in 2021

G Fahed, L Aoun, M Bou Zerdan, S Allam… - International journal of …, 2022 - mdpi.com
Metabolic syndrome (MetS) forms a cluster of metabolic dysregulations including insulin
resistance, atherogenic dyslipidemia, central obesity, and hypertension. The pathogenesis …

Diabetic vascular diseases: molecular mechanisms and therapeutic strategies

Y Li, Y Liu, S Liu, M Gao, W Wang, K Chen… - Signal transduction and …, 2023 - nature.com
Vascular complications of diabetes pose a severe threat to human health. Prevention and
treatment protocols based on a single vascular complication are no longer suitable for the …

COVID-19 and oxidative stress

BV Chernyak, EN Popova, AS Prikhodko… - Biochemistry …, 2020 - Springer
Pathogenesis of the novel coronavirus infection COVID-19 is the subject of active research
around the world. COVID-19 caused by the SARS-CoV-2 is a complex disease in which …

Particulate matter air pollution: effects on the cardiovascular system

RB Hamanaka, GM Mutlu - Frontiers in endocrinology, 2018 - frontiersin.org
Air pollution is a complex mixture of gaseous and particulate components, each of which has
detrimental effects on human health. While the composition of air pollution varies greatly …

Clinical and biological correlates of neurotoxicity associated with CAR T-cell therapy in patients with B-cell acute lymphoblastic leukemia

BD Santomasso, JH Park, D Salloum, I Riviere, J Flynn… - Cancer discovery, 2018 - AACR
CD19-specific chimeric antigen receptor (CAR) T-cell therapy is highly effective against
relapsed or refractory acute lymphoblastic leukemia (ALL), but is hindered by neurotoxicity …

[HTML][HTML] Immune-based prediction of COVID-19 severity and chronicity decoded using machine learning

BK Patterson, J Guevara-Coto, R Yogendra… - Frontiers in …, 2021 - frontiersin.org
Expression of CCR5 and its cognate ligands have been implicated in COVID-19
pathogenesis, consequently therapeutics directed against CCR5 are being investigated …

Interleukin-6 signaling pathway and its role in kidney disease: an update

H Su, CT Lei, C Zhang - Frontiers in immunology, 2017 - frontiersin.org
Interleukin-6 (IL-6) is a pleiotropic cytokine that not only regulates the immune and
inflammatory response but also affects hematopoiesis, metabolism, and organ development …

Interleukin-6: a novel target for cardio-cerebrovascular diseases

JH Su, MY Luo, N Liang, SX Gong, W Chen… - Frontiers in …, 2021 - frontiersin.org
Cardio-Cerebrovascular Disease is a collective term for cardiovascular disease and
cerebrovascular disease, being a serious threat to human health. A growing number of …

Downregulation of cytoplasmic DNases is implicated in cytoplasmic DNA accumulation and SASP in senescent cells

A Takahashi, TM Loo, R Okada, F Kamachi… - Nature …, 2018 - nature.com
Accumulating evidence indicates that the senescence-associated secretory phenotype
(SASP) contributes to many aspects of physiology and disease. Thus, controlling the SASP …

Adipokines, adiposity, and atherosclerosis

L Liu, Z Shi, X Ji, W Zhang, J Luan, T Zahr… - Cellular and Molecular …, 2022 - Springer
Characterized by a surplus of whole-body adiposity, obesity is strongly associated with the
prognosis of atherosclerosis, a hallmark of coronary artery disease (CAD) and the major …