[HTML][HTML] Regulation of gene expression via translational buffering
Translation of an mRNA represents a critical step during the expression of protein-coding
genes. As mechanisms governing post-transcriptional regulation of gene expression are …
genes. As mechanisms governing post-transcriptional regulation of gene expression are …
The effects of codon bias and optimality on mRNA and protein regulation
F Hia, O Takeuchi - Cellular and Molecular Life Sciences, 2021 - Springer
The central dogma of molecular biology entails that genetic information is transferred from
nucleic acid to proteins. Notwithstanding retro-transcribing genetic elements, DNA is …
nucleic acid to proteins. Notwithstanding retro-transcribing genetic elements, DNA is …
Selective gene expression maintains human tRNA anticodon pools during differentiation
L Gao, A Behrens, G Rodschinka, S Forcelloni… - Nature Cell …, 2024 - nature.com
Transfer RNAs are essential for translating genetic information into proteins. The human
genome contains hundreds of predicted tRNA genes, many in multiple copies. How their …
genome contains hundreds of predicted tRNA genes, many in multiple copies. How their …
Two isoleucyl tRNAs that decode synonymous codons divergently regulate breast cancer metastatic growth by controlling translation of proliferation-regulating genes
The human genome contains 61 codons encoding 20 amino acids. Synonymous codons
representing a given amino acid are decoded by a set of transfer RNAs (tRNAs) called …
representing a given amino acid are decoded by a set of transfer RNAs (tRNAs) called …
Leucyl-tRNA synthetase is a tumour suppressor in breast cancer and regulates codon-dependent translation dynamics
Tumourigenesis and cancer progression require enhanced global protein translation,–.
Such enhanced translation is caused by oncogenic and tumour-suppressive events that …
Such enhanced translation is caused by oncogenic and tumour-suppressive events that …
Transcriptome-wide sites of collided ribosomes reveal principles of translational pausing
Translation initiation is the major regulatory step defining the rate of protein production from
an mRNA. Meanwhile, the impact of nonuniform ribosomal elongation rates is largely …
an mRNA. Meanwhile, the impact of nonuniform ribosomal elongation rates is largely …
Decoding of translation‐regulating entities reveals heterogeneous translation deficiency patterns in cellular senescence
A Papaspyropoulos, O Hazapis, A Altulea… - Aging …, 2023 - Wiley Online Library
Cellular senescence constitutes a generally irreversible proliferation barrier, accompanied
by macromolecular damage and metabolic rewiring. Several senescence types have been …
by macromolecular damage and metabolic rewiring. Several senescence types have been …
Coding regions affect mRNA stability in human cells
A new paradigm has emerged that coding regions can regulate mRNA stability in model
organisms. Here, due to differences in cognate tRNA abundance, synonymous codons are …
organisms. Here, due to differences in cognate tRNA abundance, synonymous codons are …
A critical period of translational control during brain development at codon resolution
D Harnett, MC Ambrozkiewicz, U Zinnall… - Nature Structural & …, 2022 - nature.com
Translation modulates the timing and amplification of gene expression after transcription.
Brain development requires uniquely complex gene expression patterns, but large-scale …
Brain development requires uniquely complex gene expression patterns, but large-scale …
Effects of codon optimization on coagulation factor IX translation and structure: Implications for protein and gene therapies
A Alexaki, GK Hettiarachchi, JC Athey, UK Katneni… - Scientific reports, 2019 - nature.com
Synonymous codons occur with different frequencies in different organisms, a phenomenon
termed codon usage bias. Codon optimization, a common term for a variety of approaches …
termed codon usage bias. Codon optimization, a common term for a variety of approaches …