Amongst the lysosomal cysteine cathepsin family of proteases, cathepsin S (CTSS) holds
particular interest due to distinctive properties including a normal restricted expression …

Background Cysteine cathepsins are normally found in the lysosomes where they are
involved in intracellular protein turnover. Their ability to degrade the components of the …

Cathepsin S is a member of the cysteine cathepsin protease family. It is a lysosomal
protease which can promote degradation of damaged or unwanted proteins in the endo …

Biomedical research often focuses on properties that differentiate between diseased and
healthy tissue; one of the current focuses is elevated expression and altered localisation of …

Dysregulated expression and activity of cathepsin S (CTSS), a lysosomal protease and a
member of the cysteine cathepsin protease family, is linked to the pathogenesis of multiple …

Cystic fibrosis (CF) is an autosomal recessive genetic condition, predominantly of white
populations, that impacts multiple organ systems. However, it is the chronic progressive lung …

Mucociliary clearance (MCC) and submucosal glands are major components of airway
innate immunity that have impaired function in cystic fibrosis (CF). Although both of these …

Cysteine proteases are important targets for the discovery of novel therapeutics for many
human diseases. From parasitic diseases to cancer, cysteine proteases follow a common …

MicroRNAs (miRNAs) are small non-coding highly conserved RNA molecules that can act
as master regulators of gene expression in a sequence-specific manner either by translation …

Rationale: Cathepsin S (CTSS) activity is increased in bronchoalveolar lavage (BAL) fluid
from patients with cystic fibrosis (CF). This activity contributes to lung inflammation via …