Asparagine-linked glycans (N-glycans) are displayed on the majority of proteins synthesized
in the endoplasmic reticulum (ER). Removal of the outermost glucose residue recruits the …

Covering: up to April 2014 The development of drugs with broad-spectrum antiviral activities
is a long pursued goal in drug discovery. It has been shown that blocking co-opted host …

Most enveloped viruses rely on the host cell endoplasmic reticulum (ER) quality control (QC)
machinery for proper folding of glycoproteins. The key ER α-glucosidases (α-Glu) I and II of …

Although hundreds of viruses are known to cause human disease, antiviral therapies are
approved for fewer than 10. Most approved antiviral drugs target viral enzymes, most …

Glycoprotein synthesis is initiated in the endoplasmic reticulum (ER) lumen upon transfer of
a glycan (Glc 3 Man 9 GlcNAc 2) from a lipid derivative to Asn residues (N-glycosylation). N …

The infection of humans by lethal pathogens such as Ebola and other related viruses has
not been properly addressed so far. In this context, a relevant question arises: What can …

Mangroves are ecosystems with unique characteristics due to the high salinity and amount
of organic matter that house a rich biodiversity. Fungi have aroused much interest as they …

Viruses subvert the functions of their host cells to replicate and form new viral progeny. The
endoplasmic reticulum (ER) has been identified as a central organelle that governs the …

Purpose Inhibitors of intestinal alpha-glucosidases are used therapeutically to treat type 2
diabetes mellitus. Bacteria such as Actinoplanes sp. naturally produce potent alpha …

Understanding Viruses continues to set the standard for the fundamentals of virology. This
classic textbook combines molecular, clinical, and historical aspects of human viral diseases …