The Wnt/β-catenin signaling pathway exerts integral roles in embryogenesis and adult
homeostasis. Aberrant activation of the pathway is implicated in growth-associated diseases …

WNT–β-catenin signalling is involved in a multitude of developmental processes and the
maintenance of adult tissue homeostasis by regulating cell proliferation, differentiation …

Similar to normal tissue, many tumors have a hierarchical organization where tumorigenic
cancer stem cells (CSCs) differentiate into non-tumorigenic progenies. A host of studies …

The evolutionarily conserved Wnt signaling pathway plays essential roles during embryonic
development and tissue homeostasis. Notably, comprehensive genetic studies in …

The canonical WNT/β-catenin signaling pathway governs a myriad of biological processes
underlying the development and maintenance of adult tissue homeostasis, including …

The Wnt signaling pathways are a group of signal transduction pathways that play an
important role in cell fate specification, cell proliferation and cell migration. Aberrant …

Cholangiocarcinoma (CC) is typically diagnosed at an advanced stage and is refractory to
surgical intervention and chemotherapy. Despite a global increase in the incidence of CC …

Nephritis is one of the most severe complications of systemic lupus erythematosus (SLE).
One key characteristic of lupus nephritis (LN) is the deposition of immune complexes …

Wnt/β-catenin signaling is a highly conserved pathway essential for embryogenesis and
tissue homeostasis. However, deregulation of this pathway can initiate and promote human …

Throughout our life, long‐lived somatic stem cells (SSC) regenerate adult tissues both
during homeostatic processes and repair after injury. The role of aberrant regulation of SSC …