Intracellular protein synthesis, folding, and degradation are tightly controlled processes to
ensure proper protein homeostasis. The proteasome is responsible for the degradation of …

β‐cell destruction in type 1 diabetes (T1D) results from the effect of inflammation and
autoimmunity. In response to inflammatory signals, islet cells engage adaptive mechanisms …

Proteasome subunit alpha type-2 (PSMA2) is a critical component of the 20S proteasome,
which is the core particle of the 26S proteasome complex and is involved in cellular protein …

Metformin, a drug widely used in type 2 diabetes (T2D), has been shown to protect human β-
cells exposed to gluco-and/or lipotoxic conditions and those in islets from T2D donors. We …

Aims/hypothesis The inflammatory milieu characteristic of insulitis affects translation fidelity
and generates defective ribosomal products (DRiPs) that participate in autoimmune beta cell …

It has been reported that the incretin system, including regulated GLP-1 secretion and locally
expressed DPP-4, is present in pancreatic islets. In this study we comprehensively …

Autoimmune type 1 diabetes (T1D) results from the intricate crosstalk of various immune cell
types. CD8+ T cells dominate the pro-inflammatory milieu of islet infiltration (insulitis), and …

The ubiquitin–proteasome system (UPS) and autophagy are two major intracellular
proteolytic systems that are closely associated with each other. Because UPS and …

Prion diseases are a unique group of infectious chronic neurodegenerative disorders to
which there are no cures. Although prion infections do not stimulate adaptive immune …

Endoplasmic reticulum (ER) and inflammatory stress responses contribute to islet
dysfunction in type 2 diabetes (T2D). Comprehensive genomic understanding of these …