Motor behavioral deficits in the cuprizone model: Validity of the rotarod test paradigm

C Lubrich, P Giesler, M Kipp - International journal of molecular sciences, 2022 - mdpi.com
Multiple Sclerosis (MS) is a neuroinflammatory disorder, which is histopathologically
characterized by multifocal inflammatory demyelinating lesions affecting both the central …

Remyelination in multiple sclerosis: findings in the cuprizone model

H Leo, M Kipp - International Journal of Molecular Sciences, 2022 - mdpi.com
Remyelination therapies, which are currently under development, have a great potential to
delay, prevent or even reverse disability in multiple sclerosis patients. Several models are …

[HTML][HTML] An overall view of the most common experimental models for multiple sclerosis

S Dedoni, M Scherma, C Camoglio, C Siddi… - Neurobiology of …, 2023 - Elsevier
Multiple sclerosis (MS) is a complex chronic disease with an unknown etiology. It is
considered an inflammatory demyelinating and neurodegenerative disorder of the central …

Stem cell therapies for progressive multiple sclerosis

JA Smith, AM Nicaise, RB Ionescu, R Hamel… - Frontiers in cell and …, 2021 - frontiersin.org
Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system
characterized by demyelination and axonal degeneration. MS patients typically present with …

Harnessing the neural stem cell secretome for regenerative neuroimmunology

CM Willis, AM Nicaise, R Hamel, V Pappa… - Frontiers in cellular …, 2020 - frontiersin.org
Increasing evidence foresees the secretome of neural stem cells (NSCs) to confer
superimposable beneficial properties as exogenous NSC transplants in experimental …

Cell reprogramming for oligodendrocytes: A review of protocols and their applications to disease modeling and cell‐based remyelination therapies

A McCaughey‐Chapman… - Journal of Neuroscience …, 2023 - Wiley Online Library
Oligodendrocytes are a type of glial cells that produce a lipid‐rich membrane called myelin.
Myelin assembles into a sheath and lines neuronal axons in the brain and spinal cord to …

Neural stem cells: promoting axonal regeneration and spinal cord connectivity

CM de Freria, E Van Niekerk, A Blesch, P Lu - Cells, 2021 - mdpi.com
Spinal cord injury (SCI) leads to irreversible functional impairment caused by neuronal loss
and the disruption of neuronal connections across the injury site. While several experimental …

Cell-based therapeutic strategies for treatment of spinocerebellar ataxias: an update

JS Correia, S Duarte-Silva, AJ Salgado… - Neural Regeneration …, 2023 - journals.lww.com
Spinocerebellar ataxias are heritable neurodegenerative diseases caused by a cytosine-
adenine-guanine expansion, which encodes a long glutamine tract (polyglutamine) in the …

Genetic inactivation of SARM1 axon degeneration pathway improves outcome trajectory after experimental traumatic brain injury based on pathological, radiological …

DV Bradshaw Jr, AK Knutsen, A Korotcov… - Acta Neuropathologica …, 2021 - Springer
Traumatic brain injury (TBI) causes chronic symptoms and increased risk of
neurodegeneration. Axons in white matter tracts, such as the corpus callosum (CC), are …

Sex differences in the behavioural aspects of the cuprizone-induced demyelination model in mice

KF Paton, S Hong, A Biggerstaff, BM Kivell - Brain Sciences, 2022 - mdpi.com
Multiple sclerosis is an autoimmune disease characterised by demyelination in the central
nervous system. The cuprizone-induced demyelination model is often used in mice to test …