How a fungus shapes biotechnology: 100 years of Aspergillus niger research

TC Cairns, C Nai, V Meyer - Fungal biology and biotechnology, 2018 - Springer
In 1917, a food chemist named James Currie made a promising discovery: any strain of the
filamentous mould Aspergillus niger would produce high concentrations of citric acid when …

Unlocking the magic in mycelium: Using synthetic biology to optimize filamentous fungi for biomanufacturing and sustainability

C Jo, J Zhang, JM Tam, GM Church, AS Khalil… - Materials Today Bio, 2023 - Elsevier
Filamentous fungi drive carbon and nutrient cycling across our global ecosystems, through
its interactions with growing and decaying flora and their constituent microbiomes. The …

Current challenges of research on filamentous fungi in relation to human welfare and a sustainable bio-economy: a white paper

V Meyer, MR Andersen, AA Brakhage… - Fungal biology and …, 2016 - Springer
The EUROFUNG network is a virtual centre of multidisciplinary expertise in the field of fungal
biotechnology. The first academic-industry Think Tank was hosted by EUROFUNG to …

Moulding the mould: understanding and reprogramming filamentous fungal growth and morphogenesis for next generation cell factories

TC Cairns, X Zheng, P Zheng, J Sun, V Meyer - Biotechnology for Biofuels, 2019 - Springer
Filamentous fungi are harnessed as cell factories for the production of a diverse range of
organic acids, proteins, and secondary metabolites. Growth and morphology have critical …

Modular synthetic biology toolkit for filamentous fungi

L Mózsik, C Pohl, V Meyer, RAL Bovenberg… - ACS Synthetic …, 2021 - ACS Publications
Filamentous fungi are highly productive cell factories, often used in industry for the
production of enzymes and small bioactive compounds. Recent years have seen an …

Strategies and challenges for the development of industrial enzymes using fungal cell factories

J Arnau, D Yaver, CM Hjort - Grand challenges in fungal biotechnology, 2020 - Springer
Industrial enzymes have been produced from microorganisms for more than a century.
Today, a large share of enzyme products is manufactured using recombinant …

Edible mycelium bioengineered for enhanced nutritional value and sensory appeal using a modular synthetic biology toolkit

V Maini Rekdal, CRB van der Luijt, Y Chen… - Nature …, 2024 - nature.com
Filamentous fungi are critical in the transition to a more sustainable food system. While
genetic modification of these organisms has promise for enhancing the nutritional value …

Understanding and controlling filamentous growth of fungal cell factories: novel tools and opportunities for targeted morphology engineering

V Meyer, T Cairns, L Barthel, R King, P Kunz… - Fungal Biology and …, 2021 - Springer
Filamentous fungal cell factories are efficient producers of platform chemicals, proteins,
enzymes and natural products. Stirred-tank bioreactors up to a scale of several hundred m³ …

Transcriptional activation of biosynthetic gene clusters in filamentous fungi

L Mózsik, R Iacovelli, RAL Bovenberg… - … in Bioengineering and …, 2022 - frontiersin.org
Filamentous fungi are highly productive cell factories, many of which are industrial
producers of enzymes, organic acids, and secondary metabolites. The increasing number of …

Genome-based engineering of ligninolytic enzymes in fungi

MD Asemoloye, MA Marchisio, VK Gupta… - Microbial cell …, 2021 - Springer
Background Many fungi grow as saprobic organisms and obtain nutrients from a wide range
of dead organic materials. Among saprobes, fungal species that grow on wood or in polluted …