Benzothiazole (BTA) and its derivatives are the most important heterocyclic compounds,
which are common and integral feature of a variety of natural products and pharmaceutical …

Neurodegenerative disease (NDD), including Alzheimer's disease, Parkinson's disease, and
amyotrophic lateral sclerosis, are characterized by the progressive loss of neurons which …

Abstract Glycogen Synthase Kinase-3 (GSK-3) is a serine/threonine kinase which is
ubiquitously expressed and is regarded as a regulator for various cellular events and …

The world health organization (WHO) estimated that 18 million people are struck by
Alzheimer′ s disease (AD). The USA, France, Germany, and other countries launched …

(Thio) ureas ((T) Us) and benzothiazoles (BTs) each have demonstrated to have a great
variety of biological activities. When these groups come together, the 2-(thio) …

Considering the emerging importance of glycogen synthase kinase 3 beta (GSK-3β)
inhibitors in treatment of Alzheimer's disease, multi-protein structure receptor-based …

Inhibition of glycogen synthase kinase-3 (GSK-3) induces neuroprotective effects, eg
decreases β-amyloid production and reduces tau hyperphosphorylation, which are both …

The glycogen synthase kinase-3 (GSK-3) has been linked to the pathogenesis of colorectal
cancer, diabetes, cardiovascular disease, acute myeloid leukemia (AML), and Alzheimer's …

Quantifying glycogen synthase kinase-3 (GSK-3) activity in vivo using positron emission
tomography (PET) imaging is of interest because dysregulation of GSK-3 is implicated in …

Alzheimer's disease (AD) is a progressive neurodegenerative disorder. Inhibiting
acetylcholinesterase (AChE), amyloid beta (Aβ1-42) aggregation and avoiding the oxidative …