The ubiquitin system has become synonymous with the modification of lysine residues.
However, the substrate scope and diversity of the conjugation machinery have been …

The corpus callosum is a bundle of axon fibres that connects the two hemispheres of the
brain. Neurodevelopmental disorders that feature dysgenesis of the corpus callosum as a …

Ubiquitin ligases are important regulators of nervous system development, function and
disease. To date, numerous ubiquitin ligases have been discovered that regulate …

Spatially and temporally accurate termination of axon outgrowth, a process called axon
termination, is required for efficient, precise nervous system construction and wiring. The …

Eph receptor tyrosine kinases participate in a variety of normal and pathogenic processes
during development and throughout adulthood. This versatility is likely facilitated by the …

Eph receptor tyrosine kinases participate in a variety of normal and pathogenic processes
during development and throughout adulthood. This versatility is likely facilitated by the …

We present an optimized protocol for in vivo affinity purification proteomics and biochemistry
using the model organism C. elegans. We describe steps for target tagging, large-scale …

Integrin signaling plays important roles in development and disease. An adhesion signaling
network called the integrin adhesome has been principally defined using bioinformatics and …

Ubiquitin molecules modify their target protein by conjugating the amino group of lysine side
chain, thereby regulating the activity and function of most intracellular proteins. However …

Previous data demonstrate variants in hundreds of genes are causative for the formation of
neurodevelopmental disorders (NDDs). However, the molecular mechanisms associated …