Blood platelets have long been recognised to bring about primary haemostasis with
deficiencies in platelet production and function manifesting in bleeding while upregulated …

Background Small studies have implicated plasminogen activator inhibitor-1 (PAI-1) as a
predictor of cardiovascular events; however, these findings have been inconsistent. We …

Tumor microenvironment (TME) has been reported to exhibit a crucial effect in lung cancer.
Therefore, this study was aimed to investigate the genes associated with TME and develop a …

Cellular migration, over simple surfaces or through complex stromal barriers, requires
coordination between detachment/re‐adhesion cycles, involving structural components of …

High mortality rates of glioblastoma (GBM) patients are partly attributed to the invasive
behavior of tumor cells that exhibit extensive infiltration into adjacent brain tissue, leading to …

Background Plasminogen activator inhibitor type 1 (PAI-1) is the primary inhibitor of
urokinase type plasminogen activators (uPA) and tissue type plasminogen activators (tPA) …

The urokinase receptor (uPAR) was originally identified as the membrane receptor of the
serine protease urokinase (uPA), thereby implicated in the plasminogen activation cascade …

Background: The dense fibrotic stroma enveloping pancreatic tumors is a major cause of
drug resistance. Pancreatic stellate cells (PSCs) in the stroma can be activated to induce …

Background Eosinophilic esophagitis (EoE) is an allergic disease of increasing worldwide
incidence. Complications are due to tissue remodeling and involve TGF-β1–mediated …

The superfamily of serine protease inhibitors (SERPINs) are a class of inhibitors that utilise a
dynamic conformational change to trap and inhibit their target enzymes. Their powerful …