Among human leukocyte antigen (HLA)-associated disorders, celiac disease has an
immunopathogenesis that is particularly well understood. The condition is characterized by …

Immunoglobulins (Ig) play an important role in the immune system both when expressed as
antigen receptors on the cell surface of B cells and as antibodies secreted into extracellular …

During the past decade several display methods and other library screening techniques
have been developed for isolating monoclonal antibodies (mAbs) from large collections of …

Transglutaminases (Tgases) are a widely distributed group of enzymes that catalyse the
post-translational modification of proteins by the formation of isopeptide bonds. This occurs …

Coeliac disease, an inflammatory disease of the small intestine, shares key features with
autoimmune disorders, such as susceptibility genes, presence of autoantibodies and T cell …

The prevailing concept regarding the immunological function of immunoglobulin A (IgA) is
that it binds to and neutralizes pathogens to prevent infection at mucosal sites of the body …

We monitored the number of intravascular platelet-leukocyte aggregates (PLAs) and
thrombotic occlusions (TOs) by intravascular microscopy in the mesentery of rats receiving …

Background: IgA class serum autoantibodies against type 2 (tissue) transglutaminase (TG2)
bind to both intestinal and extraintestinal normal tissue sections in vitro, eliciting endomysial …

Celiac disease is an intestinal autoimmune disease driven by dietary gluten and gluten-
specific CD4+ T-cell responses. In celiac patients on a gluten-free diet, exposure to gluten …

Celiac disease (CD) is an increasingly common disease of the small intestine that occurs in
genetically susceptible subjects by ingestion of cereal gluten proteins. Gluten is highly …