Proteins exist as dynamic conformational ensembles. Here we suggest that the propensities
of the conformations can be predictors of cell function. The conformational states that the …

The key players in transcriptional regulation are transcription factors (TFs), proteins that bind
specific DNA sequences. Several mechanisms exist to turn TFs 'on'and 'off', including ligand …

Nuclear receptors are multidomain transcription factors whose full-length quaternary
architecture is poorly described and understood. Most nuclear receptors bind DNA as …

Bile acids are signaling molecules with critical roles in cholesterol and lipid metabolism,
achieved by regulating the transcriptional activity of the farnesoid X receptor (FXR, NR1H4) …

Nuclear receptors (NRs) regulate gene expression in critical physiological processes, with
their functionality finely tuned by ligand-induced conformational changes. While NRs may …

Type-II diabetes, a major metabolic disorder has threatened the very existence of a healthy
life since long ago. Commercially available antidiabetic drugs are known for several adverse …

The evolution of breast cancers results from the emergence of epithelial cell subpopulations
containing variant Estrogen Receptor α which is able to bypass conventional treatments …

Nuclear receptors are multidomain transcription factors whose full-length quaternary
architecture is poorly described and understood. Most nuclear receptors bind DNA as …

Protein conformational dynamics play a pivotal role in enzyme catalysis and hold significant
implications in bioengineering. Notably, scopoletin exerts a substantial inhibitory effect on a …