During mitosis and meiosis, the spindle assembly checkpoint acts to maintain genome
stability by delaying cell division until accurate chromosome segregation can be …

In eukaryotes, chromosome segregation during cell division is facilitated by the kinetochore,
a multiprotein structure that is assembled on centromeric DNA. The kinetochore attaches …

The spindle checkpoint ensures proper chromosome segregation during cell division.
Unravelling checkpoint signalling has been a long-standing challenge owing to the …

A critical requirement for mitosis is the distribution of genetic material to the two daughter
cells. The central player in this process is the macromolecular kinetochore structure, which …

Myc is an oncogenic transcription factor frequently dysregulated in human cancer. To
identify pathways supporting the Myc oncogenic program, we used a genome-wide RNA …

Kinetochores are the macromolecular complexes that interact with microtubules to mediate
chromosome segregation [1]. Accurate segregation requires that kinetochores make …

Bub1 is a multi-task protein kinase required for proper chromosome segregation in
eukaryotes. Impairment of Bub1 in humans may lead to chromosomal instability (CIN) or …

The genomic stability of all organisms depends on the precise partition of chromosomes to
daughter cells. The spindle assembly checkpoint (SAC) senses unattached kinetochores …

Autosomal recessive primary microcephaly (MCPH) is a neurodevelopmental disorder that
is characterised by microcephaly present at birth and non-progressive mental retardation …

Kinetochores are large protein assemblies built on chromosomal loci named centromeres.
The main functions of kinetochores can be grouped under four modules. The first module, in …