Background: Right ventricular (RV) adaptation to acute and chronic pulmonary hypertensive
syndromes is a significant determinant of short-and long-term outcomes. Although …

Heart failure with preserved ejection fraction (HFpEF) is characterized by signs and
symptoms of heart failure in the presence of a normal left ventricular ejection fraction …

Pulmonary vascular remodeling characterized by concentric wall thickening and intraluminal
obliteration is a major contributor to the elevated pulmonary vascular resistance in patients …

Decellularized extracellular matrix in the form of patches and locally injected hydrogels has
long been used as therapies in animal models of disease. Here we report the safety and …

It is well established that control of vascular morphogenesis and homeostasis is regulated
by vascular endothelial growth factor (VEGF), fibroblast growth factor (FGF), Delta-like 4 …

Pulmonary arterial hypertension (PAH) is responsible for the premature death mainly
because of progressive and severe heart failure. This disease is characterized by increased …

Pulmonary hypertension (PH) because of chronic lung disease is categorized as Group 3
PH in the most recent classification system. Prevalence of these diseases is increasing over …

Despite recent therapeutic advances, pulmonary hypertension (PH) remains a fatal disease
due to the development of right ventricular (RV) failure. At present, no treatments targeted at …

The low-density lipoprotein receptor (LDLR) gene family includes LDLR, very LDLR, and
LDL receptor–related proteins (LRPs) such as LRP1, LRP1b (aka LRP-DIT), LRP2 (aka …

Highlights•Dysregulation of the BMP–TGFβ axis is a major concern in pulmonary arterial
hypertension.•Reduced BMPRII expression causes an imbalance of BMP–TGFβ …