Advances in the development of anti-Toxoplasma gondii vaccines: challenges, opportunities, and perspectives

JL Wang, NZ Zhang, TT Li, JJ He, HM Elsheikha… - Trends in …, 2019 - cell.com
Important progress has been made in understanding how immunity is elicited against
Toxoplasma gondii–a complex pathogen with multiple mechanisms of immune evasion …

Vaccines against Toxoplasma gondii: new developments and perspectives

NZ Zhang, J Chen, M Wang, E Petersen… - Expert review of …, 2013 - Taylor & Francis
Toxoplasmosis caused by the protozoan Toxoplasma gondii is a major public health
problem, infecting one-third of the world human beings, and leads to abortion in domestic …

Recent advances in the development of adenovirus-vectored vaccines for parasitic infections

C Koger-Pease, DJ Perera, M Ndao - Pharmaceuticals, 2023 - mdpi.com
Vaccines against parasites have lagged centuries behind those against viral and bacterial
infections, despite the devastating morbidity and widespread effects of parasitic diseases …

Toxoplasma gondii surface antigen 1 (SAG1) as a potential candidate to develop vaccine against toxoplasmosis: A systematic review

AS Pagheh, S Sarvi, M Sharif, F Rezaei… - … and Infectious Diseases, 2020 - Elsevier
Toxoplasma gondii is an intracellular parasite that infects a broad range of animal species
and humans. As the main surface antigen of the tachyzoite, SAG1 is involved in the process …

Multi-epitope vaccine expressed in Leishmania tarentolae confers protective immunity to Toxoplasma gondii in BALB/c mice

H Majidiani, A Dalimi, F Ghaffarifar, M Pirestani - Microbial Pathogenesis, 2021 - Elsevier
Current study deals with a novel multi-epitope vaccine designed in silico and its confirmation
experiments for potential efficacy in BALB/c mice. Major histocompatibility complex (MHC) …

The virulence-related rhoptry protein 5 (ROP5) of Toxoplasma gondii is a novel vaccine candidate against toxoplasmosis in mice

B Zheng, S Lu, Q Tong, Q Kong, D Lou - Vaccine, 2013 - Elsevier
Infections with the intracellular protozoan parasite Toxoplasma gondii pose a serious public
health problem and are of great economic importance worldwide. The parasite rhoptry …

Towards an immunosense vaccine to prevent toxoplasmosis: protective Toxoplasma gondii epitopes restricted by HLA-A* 0201

H Cong, EJ Mui, WH Witola, J Sidney, J Alexander… - Vaccine, 2011 - Elsevier
The ideal vaccine to protect against toxoplasmosis in humans would include antigens that
elicit a protective T helper cell type 1 immune response, and generate long-lived IFN-γ …

Ginsenoside Rg1 enhances immune response induced by recombinant Toxoplasma gondii SAG1 antigen

DF Qu, HJ Yu, Z Liu, DF Zhang, QJ Zhou… - Veterinary …, 2011 - Elsevier
Ginsenoside, the most important component isolated from Panax ginseng, exhibits a variety
of biological activities. Particularly, ginsenoside Rg1 is known to have immune-modulating …

DNA prime and peptide boost immunization protocol encoding the Toxoplasma gondii GRA4 induces strong protective immunity in BALB/c mice

M Meng, A Zhou, G Lu, L Wang, G Zhao, Y Han… - BMC infectious …, 2013 - Springer
Background Toxoplasma gondii is a widespread intracellular parasite, which infects most
vertebrate animal hosts and causes zoonotic infection in humans. Vaccine strategy remains …

Intranasal influenza-vectored vaccine expressing pneumococcal surface protein A protects against Influenza and Streptococcus pneumoniae infections

KF Cardoso, LRA de Souza, BSÁ da Silva Santos… - npj Vaccines, 2024 - nature.com
Streptococcus pneumoniae and influenza A virus (IAV) are significant agents of pneumonia
cases and severe respiratory infections globally. Secondary bacterial infections, particularly …