A well-regulated redox state is essential for normal physiological function and cellular
metabolism. In most eukaryotic cells, protein cysteine thiols are most sensitive to fluctuations …

Background Different chemical toxicants or natural toxins can damage human health
through various routes such as air, water, fruits, foods, and vegetables. Purpose Herbal …

Mitochondrial permeability transition pore (mPTP) is involved in cardiac dysfunction during
chronic β-adrenergic receptor (β-AR) stimulation. The mechanism by which chronic β-AR …

Abstract Although High Intensity Interval Training (HIIT) are being associated to increase
cardiovascular and metabolic adaptation, there is controversy and limited information about …

Mitochondria play a critical role in mediating the cellular response to oxidants formed during
acute and chronic cardiac dysfunction. It is widely assumed that, as cells are subjected to …

Background—Although preclinical data suggested that tumor necrosis factor-α (TNF)
neutralization in heart failure (HF) would be beneficial, clinical trials of TNF antagonists were …

Background—Heme oxygenase-1 (HO-1) is an inducible stress-response protein that
imparts antioxidant and antiapoptotic effects. However, its pathophysiological role in cardiac …

The present study was designed to investigate whether fluvastatin, a 3-hydroxy-3-
methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor, would attenuate the acute …

Key point• β‐Adrenergic receptor (β‐AR) stimulation is the most important positive inotropic
effect on the heart, but it can also induce cardiac arrhythmias.• In rabbit ventricular myocytes …

Endogenous histidyl dipeptides such as carnosine (β-alanine-l-histidine) form conjugates
with lipid peroxidation products such as 4-hydroxy-trans-2-nonenal (HNE and acrolein) …