Neurodevelopmental diseases (NDDs), such as autism spectrum disorders, epilepsy, and
schizophrenia, are characterized by diverse facets of neurological and psychiatric …

Proper brain development essentially depends on the timed availability of sufficient amounts
of thyroid hormone (TH). This, in turn, necessitates a tightly regulated expression of TH …

Species differences in brain and blood–brain barrier (BBB) biology hamper the translation of
findings from animal models to humans, impeding the development of therapeutics for brain …

Detailing how primate and mouse neurons differ is critical for creating generalized models of
how neurons process information. We reconstruct 15,748 synapses in adult Rhesus …

Abstract Transcription factor 4 (TCF4) is a basic helix-loop-helix transcription factor that is
implicated in a variety of psychiatric disorders including autism spectrum disorder (ASD) …

Promoters are essential tools for basic and translational neuroscience research. An ideal
promoter should possess the shortest possible DNA sequence with cell-type selectivity …

N-methyl-D-aspartate receptor (NMDAR) modulators have recently received increased
attention as potential therapeutics for posttraumatic stress disorder (PTSD). Here, we tested …

Mammalian neocortex contains a highly diverse set of cell types. These types have been
mapped systematically using a variety of molecular, electrophysiological and morphological …

Background Many neuropsychiatric disorders develop in early life. Although the
mechanisms involved have not been elucidated, it is possible that functional abnormalities …

GABAergic inhibitory interneurons, originating from the embryonic ventral forebrain
territories, traverse a convoluted migratory path to reach the neocortex. These interneuron …