This chapter includes a historic overview of 14-3-3 proteins with an emphasis on the
differences between potentially cancer-relevant isoforms on the genomic, protein and …

The 14-3-3 proteins, a family of conserved regulatory molecules, participate in a wide range
of cellular processes through binding interactions with hundreds of structurally and …

The seven members of the human 14-3-3 protein family regulate a diverse range of cell
signaling pathways by formation of protein–protein complexes with signaling proteins that …

14-3-3 proteins play critical roles in the regulation of cell fate through phospho-dependent
binding to a large number of intracellular proteins that are targeted by various classes of …

Co-ordinated progression through the cell cycle is essential for the maintenance of genomic
integrity. Several checkpoint mechanisms guarantee that the next step in cell cycle …

3-3 is a highly conserved acidic protein family, composed of seven isoforms in mammals. 14-
3-3 protein can interact with over 200 target proteins by phosphoserine-dependent and …

The 14-3-3 proteins are a family of highly conserved, multifunctional proteins that are highly
expressed in the brain during development. Cumulatively, the seven 14-3-3 isoforms make …

14-3-3 proteins are a ubiquitous class of regulatory proteins found in all eukaryotic cells and
were the first class of molecules to be recognized as discrete phosphoserine/threonine …

Abstract The seven 14-3-3 isoforms are highly abundant human proteins encoded by similar
yet distinct genes. 14-3-3 proteins recognize phosphorylated motifs within numerous human …

Regulation of inflammation is a central part of the maintenance of homeostasis by the
immune system. One important class of regulatory protein that has been shown to have …