Chlorinative stress: an under appreciated mediator of neurodegeneration?

YW Yap, M Whiteman, NS Cheung - Cellular signalling, 2007 - Elsevier
Oxidative stress has been implicated as playing a role in neurodegenerative disorders, such
as ischemic stroke, Alzheimer's, Huntington's, and Parkinson's disease. Persuasive …

Progress in reducing the pale, soft and exudative (PSE) problem in pork and poultry meat

S Barbut, AA Sosnicki, SM Lonergan, T Knapp… - Meat science, 2008 - Elsevier
Research in the area of the pale, soft and exudative (PSE) pork and poultry meat is reviewed
in this article with an emphasis on genetic, biochemical and metabolic factors contributing to …

Functional consequences of oxidative membrane damage

G Stark - The Journal of membrane biology, 2005 - Springer
The interaction of reactive oxygen species with biological membranes is known to produce a
great variety of different functional modifications. Part of these modifications may be …

Comparative reactivity of myeloperoxidase-derived oxidants with mammalian cells

BS Rayner, DT Love, CL Hawkins - Free Radical Biology and Medicine, 2014 - Elsevier
Myeloperoxidase is an important heme enzyme released by activated leukocytes that
catalyzes the reaction of hydrogen peroxide with halide and pseudo-halide ions to form …

Hypochlorous acid induces apoptosis of cultured cortical neurons through activation of calpains and rupture of lysosomes

YW Yap, M Whiteman, BH Bay, Y Li… - Journal of …, 2006 - Wiley Online Library
Chlorotyrosine, a bio‐marker of hypochlorous acid (HOCl) in vivo, was reported to be
substantially elevated in the Alzheimer's disease (AD) brains. Thus, HOCl might be …

Redox control of calcium channels: from mechanisms to therapeutic opportunities

LC Hool, B Corry - Antioxidants and Redox Signaling, 2007 - liebertpub.com
Calcium plays an integral role in cellular function. It is a well-recognized second messenger
necessary for signaling cellular responses, but in excessive amounts can be deleterious to …

[图书][B] Окислительно-восстановительные процессы в клетках

Достижения клеточной биофизики последних лет привели к существенным
изменениям представлений о роли окислительно-восстановительных процессов в …

Myeloperoxidase exacerbates secondary injury by generating highly reactive oxygen species and mediating neutrophil recruitment in experimental spinal cord injury

K Kubota, H Saiwai, H Kumamaru, T Maeda, Y Ohkawa… - Spine, 2012 - journals.lww.com
Study Design. An animal study using myeloperoxidase-knockout (MPO-KO) mice to examine
the in vivo role of myeloperoxidase (MPO) in spinal cord injury (SCI). Objective. To clarify the …

[HTML][HTML] HOCl causes necrotic cell death in human monocyte derived macrophages through calcium dependent calpain activation

YT Yang, M Whiteman, SP Gieseg - Biochimica et Biophysica Acta (BBA) …, 2012 - Elsevier
The abundance of dead macrophages in close proximity to HOCl-modified proteins in
advanced atherosclerotic plaques implicates HOCl in the killing of macrophages and the …

Myeloperoxidase-derived oxidants inhibit sarco/endoplasmic reticulum Ca2+-ATPase activity and perturb Ca2+ homeostasis in human coronary artery endothelial …

NL Cook, HM Viola, VS Sharov, LC Hool… - Free Radical Biology …, 2012 - Elsevier
The sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) plays a critical role in Ca2+
homeostasis via sequestration of this ion in the sarco/endoplasmic reticulum. The activity of …