Nucleoside, nucleotide, and base analogs have been in the clinic for decades to treat both
viral pathogens and neoplasms. More than 20% of patients on anticancer chemotherapy …

Boron neutron capture therapy (BNCT) is a potential cancer radiotherapeutic modality,
which takes advantage of the neutron capture response that occurs when boron (10 B) is …

INTRODUCTION Fluctuations have long been known to dynamically shape microstate
distributions in physical systems. Throughout engineering,“dithering” approaches that …

Ribonucleotide reductases (RNRs) transform RNA building blocks to DNA building blocks
by catalyzing the substitution of the 2′ OH-group of a ribonucleotide with a hydrogen by a …

Inhibition of cellular replication is one characteristic of cancer cells that has been effectively
exploited in the past for the development of anticancer agents. Most of the drugs currently …

Biochemical modulation is the manipulation of cellular biochemical pathways by chemical
agents to produce selective enhancement of the efficacy of an antitumor drug. 1 Since the …

Twenty-five years ago, nucleoside analog 3′-azidothymidine (AZT) was shown to efficiently
block the replication of HIV in cell culture. Subsequent studies demonstrated that AZT acts …

Highly active antiretroviral therapy (HAART) regimes based on nucleoside reverse
transcriptase inhibitors (NRTIs) have revolutionized the treatment of AIDS in recent years …

Nucleoside analogues (NA) are essential components of AML induction therapy (cytosine
arabinoside), effective treatments of lymphoproliferative disorders (fludarabine, cladribine) …

Background Chemogenetic profiling enables the identification of gene mutations that
enhance or suppress the activity of chemical compounds. This knowledge provides insights …