Neurodegeneration and its loss of cognitive function is associated with inflammation and an
accumulation of lipids. In the periphery, cholesterol's uptake drives a major component of …

Low levels of high-density lipoprotein (HDL) and impaired HDL functionality have been
consistently associated with increased susceptibility to infection and its serious …

Membrane fusion occurs at the early stages of SARS-CoV-2 replication, during entry of the
virus, and later during the formation of multinucleated cells called syncytia. Fusion is …

COVID-19, caused by the SARS-CoV-2 coronavirus, emerged as a global pandemic in late
2019, resulting in significant global public health challenges. The emerging evidence …

Patients with chronic lung disease, obesity, and other co-morbid conditions are at increased
risk of severe illness and death when infected with severe acute respiratory syndrome …

The rapid development of vaccines to combat severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) infections has been critical to reduce the severity of COVID-19 …

Abstract Background The Niemann Pick C1 (NPC1) protein is an intracellular cholesterol
transporter located in the late endosome/lysosome (LE/Ly) that is involved in the …

ACE2, part of the angiotensin-converting enzyme family and the renin–angiotensin–
aldosterone system (RAAS), plays vital roles in cardiovascular and renal functions. It is also …

Infections with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) cause
coronavirus disease 2019 (COVID-19), a disease with very heterogeneous symptoms …

Viral envelope fusion with the host plasma membrane (PM) for genome release is a
hallmark step in the life cycle of many enveloped viruses. This process is regulated by a …