Advanced techniques for detecting protein misfolding and aggregation in cellular environments
Protein misfolding and aggregation, a key contributor to the progression of numerous
neurodegenerative diseases, results in functional deficiencies and the creation of harmful …
neurodegenerative diseases, results in functional deficiencies and the creation of harmful …
Physicochemical properties of cells and their effects on intrinsically disordered proteins (IDPs)
FX Theillet, A Binolfi, T Frembgen-Kesner… - Chemical …, 2014 - ACS Publications
It has long been axiomatic that a protein's structure determines its function. Intrinsically
disordered proteins (IDPs) and disordered protein regions (IDRs) defy this structure …
disordered proteins (IDPs) and disordered protein regions (IDRs) defy this structure …
[图书][B] Biologia molecular da célula
À medida que a quantidade de informações em biologia aumenta exponencialmente, é
cada vez mais importante que os livros tenham a capacidade de transformar grandes …
cada vez mais importante que os livros tenham a capacidade de transformar grandes …
[HTML][HTML] MAVS forms functional prion-like aggregates to activate and propagate antiviral innate immune response
In response to viral infection, RIG-I-like RNA helicases bind to viral RNA and activate the
mitochondrial protein MAVS, which in turn activates the transcription factors IRF3 and NF-κB …
mitochondrial protein MAVS, which in turn activates the transcription factors IRF3 and NF-κB …
Protein misfolding, functional amyloid, and human disease
Peptides or proteins convert under some conditions from their soluble forms into highly
ordered fibrillar aggregates. Such transitions can give rise to pathological conditions ranging …
ordered fibrillar aggregates. Such transitions can give rise to pathological conditions ranging …
The tip of the iceberg: RNA-binding proteins with prion-like domains in neurodegenerative disease
Prions are self-templating protein conformers that are naturally transmitted between
individuals and promote phenotypic change. In yeast, prion-encoded phenotypes can be …
individuals and promote phenotypic change. In yeast, prion-encoded phenotypes can be …
Transgenerational epigenetic inheritance: prevalence, mechanisms, and implications for the study of heredity and evolution
E Jablonka, G Raz - The Quarterly review of biology, 2009 - journals.uchicago.edu
This review describes new developments in the study of transgenerational epigenetic
inheritance, a component of epigenetics. We start by examining the basic concepts of the …
inheritance, a component of epigenetics. We start by examining the basic concepts of the …
Molecular structural basis for polymorphism in Alzheimer's β-amyloid fibrils
AK Paravastu, RD Leapman… - Proceedings of the …, 2008 - National Acad Sciences
We describe a full structural model for amyloid fibrils formed by the 40-residue β-amyloid
peptide associated with Alzheimer's disease (Aβ1–40), based on numerous constraints from …
peptide associated with Alzheimer's disease (Aβ1–40), based on numerous constraints from …
Biology and genetics of prions causing neurodegeneration
SB Prusiner - Annual review of genetics, 2013 - annualreviews.org
Prions are proteins that acquire alternative conformations that become self-propagating.
Transformation of proteins into prions is generally accompanied by an increase in β-sheet …
Transformation of proteins into prions is generally accompanied by an increase in β-sheet …