Plasma HDL-cholesterol concentrations correlate negatively with the risk of atherosclerotic
cardiovascular disease (ASCVD). According to a widely cited model, HDL elicits its …

Biological membranes are tricky to investigate. They are complex in terms of molecular
composition and structure, functional over a wide range of time scales, and characterized by …

Background In observational analyses, higher levels of high-density lipoprotein (HDL)
cholesterol have been associated with a lower risk of coronary heart disease events …

A biomarker can be a substance or structure measured in body parts, fluids or products that
can affect or predict disease incidence. As age-related macular degeneration (AMD) is the …

The development of CETP (cholesteryl ester transfer protein) inhibitors has had a long and
difficult course with 3 compounds failing in phase III clinical trials. Finally, the REVEAL …

There is an urgency to find new treatment strategies that could prevent or delay the onset or
progression of AMD. Different classes of lipids and lipoproteins metabolism genes have …

Since the discovery in the 1970s that plasma levels of high-density lipoprotein cholesterol
(HDL-C) are inversely associated with cardiovascular outcome, it has been postulated that …

Cholesteryl ester transfer protein (CETP) promotes the transfer of cholesteryl esters from
antiatherogenic HDLs to proatherogenic apolipoprotein B (apoB)–containing lipoproteins …

Several new or emerging drugs for dyslipidemia owe their existence, in part, to human
genetic evidence, such as observations in families with rare genetic disorders or in …

Background Dalcetrapib modulates cholesteryl ester transfer protein (CETP) activity to raise
high-density lipoprotein cholesterol (HDL-C). After the failure of torcetrapib it was unknown if …