Emerging and reemerging infectious diseases have a strong negative impact on public
health. However, because many of these pathogens must be handled in biosafety level, 3 or …

The host range of retroviral vectors including lentiviral vectors can be expanded or altered
by a process known as pseudotyping. Pseudotyped lentiviral vectors consist of vector …

A major challenge in understanding SARS-CoV-2 evolution is interpreting the antigenic and
functional effects of emerging mutations in the viral spike protein. Here, we describe a deep …

A major impediment to the successful application of gene therapy for the treatment of a
range of diseases is not a paucity of therapeutic genes, but the lack of an efficient non‐toxic …

Retargeting of lentiviral vector entry to cell types of interest is a key factor in improving the
safety and efficacy of gene transfer. In this study we show that the retargetable envelope …

Viruses have evolved specialized molecular mechanisms to transfer their genome efficiently
into host cells. Viruses can be repurposed into viral vectors to achieve controlled gene …

Abstract (See the editorial commentary by Bausch, on pages 179–81.) Background. Reston
ebolavirus was recently detected in pigs in the Philippines. Specific antibodies were found in …

Cellular cathepsins are required for Ebola virus infection and are believed to proteolytically
process the Ebola virus glycoprotein (GP) during entry. However, the significance of …

Gene therapy for cystic fibrosis (CF) is making encouraging progress into clinical trials.
However, further improvements in transduction efficiency are desired. To develop a novel …

Rationale: Ongoing efforts to improve pulmonary gene transfer thereby enabling gene
therapy for the treatment of lung diseases, such as cystic fibrosis (CF), has led to the …