Mounting evidence suggests safety and efficacy of psychedelic compounds as potential
novel therapeutics in psychiatry. Ketamine has been approved by the Food and Drug …

This paper introduces a new construct, the 'pivotal mental state', which is defined as a hyper-
plastic state aiding rapid and deep learning that can mediate psychological transformation …

Psychedelics are a broad class of drugs defined by their ability to induce an altered state of
consciousness,. These drugs have been used for millennia in both spiritual and medicinal …

Background: Meta-analysis of randomized studies using lysergic acid diethylamide (LSD) for
alcohol use disorder (AUD) showed large, significant effects for LSD efficacy compared to …

methoxy‐N, N‐dimethyltryptamine (5‐MeO‐DMT) is a naturally occurring tryptamine that
primarily acts as an agonist at the 5‐HT1A and 5‐HT2A receptors, whereby affinity for the 5 …

Patients characterized by stress-related disorders such as depression display elevated
circulating concentrations of pro-inflammatory cytokines and a hyperactive HPA axis …

The discovery of ketamine as a rapid-acting antidepressant spurred significant research to
understand its underlying mechanisms of action and to identify other novel compounds that …

Background The glutamatergic modulator ketamine has created a blueprint for studying
novel pharmaceuticals in the field. Recent studies suggest that “classic” serotonergic …

Bipolar disorder is a decidedly heterogeneous and multifactorial disease, with a high
individual and societal burden. While not all patients display overt markers of elevated …

Background Observational data and preliminary studies suggest serotonin 2A agonist
psychedelics may hold potential in treating a variety of substance use disorders (SUDs) …