Objective To summarize the application of non-targeted metabolomics in epidemiological
studies that assessed metabolite and metabolic pathway alterations associated with per-and …

The levels of the thousands of metabolites in the human plasma metabolome are strongly
influenced by an individual's genetics and the composition of their diet and gut microbiome …

5-Aminovaleric acid betaine (5-AVAB) is a trimethylated compound associated with the gut
microbiota, potentially produced endogenously, and related to the dietary intake of certain …

Background: The human heart primarily metabolizes fatty acids, and this decreases as
alternative fuel use rises in heart failure with reduced ejection fraction (HFrEF). Patients with …

Obesity, diabetes, and hypertension have increased by epidemic proportions in recent years
among African Americans in comparison to Whites resulting in significant adverse …

Background Myxomatous mitral valve disease (MMVD), a naturally occurring heart disease,
affects 10% to 15% of the canine population. Canine MMVD shares many similarities with …

Owing to the overwhelming obesity epidemic, preserved ejection fraction heart failure
commonly ensues in patients with severe obesity and the obese phenotype of preserved …

Background Ageing and insulin resistant states such as diabetes mellitus frequently coexist
and increase the risk of cardiovascular disease development among older adults. Here we …

Heart failure with preserved ejection fraction is a growing epidemic and accounts for half of
all patients with heart failure. Increasing prevalence, morbidity, and clinical inertia have …

Growing interest lies in the assessment of the metabolic status of patients with a
univentricular circulation after Fontan operation, especially in changes of amino acid …