The Eph receptors are the largest of the RTK families. Like other RTKs, they transduce
signals from the cell exterior to the interior through ligand-induced activation of their kinase …

Critical roles for EPH receptor (EPH)–ephrin signalling in a range of chronic and
regenerative diseases are increasingly being recognized. In particular, the complex roles of …

Cellular senescence prevents the proliferation of cells at risk for neoplastic transformation.
However, the altered secretome of senescent cells can promote the growth of the …

Eph receptors and the corresponding Eph receptor-interacting (ephrin) ligands jointly
constitute a critical cell signaling network that has multiple functions. The tyrosine kinase …

Eph receptor tyrosine kinases mould the behaviour of many cell types by binding membrane-
anchored ligands, ephrins, at sites of cell–cell contact. Eph signals affect both of the …

Activation of the EphA2 receptor tyrosine kinase by ephrin-A1 ligands presented on
apposed cell surfaces plays important roles in development and exhibits poorly understood …

Importance of the field: High mortality rates with cancers warrant further development of
earlier diagnostics and better treatment strategies. Membrane-bound erythropoietin …

The Eph receptor tyrosine kinases and ephrin ligands have been studied extensively for
their roles in developmental processes. In recent years, Eph receptors and ephrins have …

Eph receptor tyrosine kinases and ephrins have key roles in regulation of the migration and
adhesion of cells required to form and stabilize patterns of cell organization during …

The Eph receptors comprise the largest group of receptor tyrosine kinases and are found in
a wide variety of cell types in developing and mature tissues. Their ligands are the ephrins, a …