Adipose tissue, colloquially known as" fat," is an extraordinarily flexible and heterogeneous
organ. While historically viewed as a passive site for energy storage, we now appreciate that …

Brown and beige adipocytes are mitochondria-enriched cells capable of dissipating energy
in the form of heat. These thermogenic fat cells were originally considered to function solely …

Brown and beige adipocytes can catabolize stored energy to generate heat, and this distinct
capacity for thermogenesis could be leveraged as a therapy for metabolic diseases like …

The worldwide incidence of obesity and its sequelae, such as type 2 diabetes mellitus, have
reached pandemic levels. Central to the development of these metabolic disorders is …

Brown adipose tissue (BAT) displays the unique capacity to generate heat through
uncoupled oxidative phosphorylation that makes it a very attractive therapeutic target for …

De novo lipogenesis (DNL) is a complex and highly regulated process in which
carbohydrates from circulation are converted into fatty acids that are then used for …

Cold-induced thermogenesis (CIT) is widely studied as a potential avenue to treat obesity,
but a thorough understanding of the metabolic changes driving CIT is lacking. Here, we …

The demonstration of metabolically active brown adipose tissue (BAT) in humans primarily
using positron emission tomography coupled to computed tomography (PET/CT) with the …

Adipose tissue possesses the remarkable capacity to control its size and function in
response to a variety of internal and external cues, such as nutritional status and …

Mammals have two types of thermogenic adipocytes: brown adipocytes and beige
adipocytes. Thermogenic adipocytes express high levels of uncoupling protein 1 (UCP1) to …