The complement system is crucial for immune surveillance, providing the body's first line of
defence against pathogens. However, an imbalance in its regulators can lead to …

Inherited retinal dystrophies (IRDs) as well as genetically complex retinal phenotypes
represent a heterogenous group of ocular diseases, both on account of their phenotypic and …

Doyne honeycomb retinal dystrophy (DHRD), also termed malattia leventinese (MLVT), is a
dominantly inherited ocular disease characterized by the progressive accumulation of …

It is known that the actin cytoskeleton and its associated cellular interactions in the
trabecular meshwork (TM) and juxtacanalicular tissues mainly contribute to the formation of …

Purpose: Localized diseases can be affected by and affect the systemic environment via
blood circulation. In this study, we explored the differences in circulating serum mRNAs …

Purpose: Activation of the classical complement pathway is thought to contribute to the
development and progression of glaucoma. The role of alternative complement or …

The complement cascade is a vital system in the human body's defense against pathogens.
During the natural aging process, it has been observed that this system is imperative for …

Chronic, unresolved inflammation has long been speculated to serve as an initiating and
propagating factor in numerous neurodegenerative diseases, including a leading cause of …

Myopia (short-sightedness) is the most common ocular disorder. It generally develops after
over-exposure to aberrant visual environments, disrupting emmetropization mechanisms …

Purpose: To assess if drusen volume can serve as structural clinical outcome marker in
Malattia Leventinese (ML), and to evaluate whether cones or rods are more affected by its …