Fibroblasts are highly dynamic cells that play a central role in tissue repair and fibrosis.
However, the mechanisms by which they contribute to both physiologic and pathologic …

All implanted biomaterials are targets of the host's immune system. While the host
inflammatory response was once considered a detrimental force to be blunted or avoided, in …

Wound healing is one of the most complex processes in the human body. It involves the
spatial and temporal synchronization of a variety of cell types with distinct roles in the …

Microporous annealed particle (MAP) scaffolds are flowable, in situ crosslinked,
microporous scaffolds composed of microgel building blocks and were previously shown to …

Regeneration is the holy grail of tissue repair, but skin injury typically yields fibrotic, non-
functional scars. Developing pro-regenerative therapies requires rigorous understanding of …

Wound healing studies are intricate, mainly because of the multifaceted nature of the wound
environment and the complexity of the healing process, which integrates a variety of cells …

Chronic wounds, particularly those associated with diabetes mellitus, represent a growing
threat to public health, with additional notable economic impacts. Inflammation associated …

Platelets are known to enhance the wound-healing activity of mesenchymal stem cells
(MSCs). However, the mechanism by which platelets improve the therapeutic potential of …

Injectable hydrogels can provide a scaffold for in situ tissue regrowth and regeneration, yet
gel degradation before tissue reformation limits the gels' ability to provide physical support …

Animal models have been developed to study the complex cellular and biochemical
processes of wound repair and to evaluate the efficacy and safety of potential therapeutic …