Kinetoplast DNA (kDNA) is the most structurally complex mitochondrial DNA in nature.
Unique to the single mitochondrion of unicellular ffagellates of the order Kinetoplastida …

One of the most fascinating and unusual features of trypanosomatids, parasites that cause
disease in many tropical countries, is their mitochondrial DNA. This genome, known as …

Kinetoplastid protozoa such as trypanosomes and Leishmania are important because they
cause human disease. These parasites are named after one of their most unusual features …

Trypanosoma cruzi acute infections often go unperceived, but one third of chronically
infected individuals die of Chagas disease, showing diverse manifestations affecting the …

In trypanosomes, the large mitochondrial genome within the kinetoplast is physically
connected to the flagellar basal bodies and is segregated by them during cell growth. The …

Kinetoplastids are flagellated protozoans, whose members include the pathogens
Trypanosoma brucei, T. cruzi and Leishmania species, that are considered among the …

Kinetoplast DNA (kDNA), the mitochondrial DNA of flagellated protozoa of the order
Kinetoplastida, is unique in its structure, function and mode of replication. It consists of few …

Mitochondrial DNA replication is an essential process in most eukaryotes. Similar to the
diversity in mitochondrial genome size and organization in the different eukaryotic …

Kinetoplast DNA (kDNA), the unusual mitochondrial DNA of Trypanosoma brucei, is a
network containing thousands of catenated circles. Database searching for a kDNA …

We studied the function of a Trypanosoma brucei topoisomerase II using RNA interference
(RNAi). Expression of a topoisomerase II double‐stranded RNA as a stem–loop caused …