Notch signaling is an evolutionarily highly conserved signaling mechanism, but in contrast to
signaling pathways such as Wnt, Sonic Hedgehog, and BMP/TGF-β, Notch signaling occurs …

The Notch signalling pathway is evolutionarily conserved and is crucial for the development
and homeostasis of most tissues. Deregulated Notch signalling leads to various diseases …

Notch signaling regulates many aspects of metazoan development and tissue renewal.
Accordingly, the misregulation or loss of Notch signaling underlies a wide range of human …

Robust type-I interferon (IFN-α/β) induction in plasmacytoid dendritic cells, through the
activation of Toll-like receptor 9 (TLR9), constitutes a critical aspect of immunity,,,,,. It is …

Notch signaling induced by canonical Notch ligands is critical for normal embryonic
development and tissue homeostasis through the regulation of a variety of cell fate decisions …

We identified two novel mouse mutants with abnormal head-shaking behavior and neural
tube defects during the course of independent ENU mutagenesis experiments. The …

Sensory hair cells and their associated non-sensory supporting cells in the inner ear are
fundamental for hearing and balance. They arise from a common progenitor, but little is …

Notch signaling regulates a vast array of crucial developmental processes. It is therefore not
surprising that mutations in genes encoding Notch receptors or ligands lead to a variety of …

During embryonic development of the inner ear, the sensory primordium that gives rise to
the organ of Corti from within the cochlear epithelium is patterned into a stereotyped array of …

Alagille syndrome is a human autosomal dominant developmental disorder characterized by
liver, heart, eye, skeletal, craniofacial and kidney abnormalities. Alagille syndrome is caused …