Autophagy, a multistep lysosomal degradation pathway that supports nutrient recycling and
metabolic adaptation, has been implicated as a process that regulates cancer. Although …

The highly conserved protein kinase mechanistic target of rapamycin (mTOR; originally
known as mammalian target of rapamycin) is a central cell growth regulator connecting …

Inhibition of the protein kinase mechanistic target of rapamycin (mTOR) with the Food and
Drug Administration (FDA)-approved therapeutic rapamycin promotes health and longevity …

The mechanistic target of rapamycin complex 1 (mTORC1) is an essential regulator of cell
growth and metabolism through the modulation of protein and lipid synthesis, lysosome …

Simple Summary In this review, we describe arginine's role as a signaling metabolite,
epigenetic regulator and mitochondrial modulator in cancer cells, and summarize recent …

Phosphatidylinositide 3 kinases (PI3Ks) and their downstream mediators AKT and
mammalian target of rapamycin (mTOR) constitute the core components of the …

Cells and organisms must coordinate their metabolic activity with changes in their
environment to ensure their growth only when conditions are favourable. In order to maintain …

The mechanistic target of rapamycin (mTOR) network is an evolutionary conserved signaling
hub that senses and integrates environmental and intracellular nutrient and growth factor …

Macroautophagy is a lysosomal degradative pathway or recycling process that maintains
cellular homeostasis. This autophagy involves a series of sequential processing events …

Amino acid transporters (AATs) are membrane-bound transport proteins that mediate
transfer of amino acids into and out of cells or cellular organelles. AATs have diverse …