Hyaluronan (HA), a major component of the extracellular matrix (ECM), plays a key role in
regulating inflammation. Inflammation is associated with accumulation and turnover of HA …

Hyaluronan is a simple repeating disaccharide polymer, synthesized at the cell surface by
integral membrane synthases. The repeating sequence is perfectly homogeneous, and is …

While conventional approaches for inflammatory bowel diseases mainly focus on
suppressing hyperactive immune responses, it remains unclear how to address disrupted …

As a result of its ability to target certain drugs and/or peptides to the colonic region for the
treatment of several diseases while avoiding systemic absorption and potential side effects …

Inflammatory bowel disease (IBD) is characterized by the high level of reactive oxygen
species (ROS) and highly dysfunctional intestinal flora. Here, a stimulation-responsive …

The cell-surface glycoprotein CD44 is involved in a multitude of important physiological
functions including cell proliferation, adhesion, migration, hematopoiesis, and lymphocyte …

Hyaluronan (HA) is a naturally occurring non-sulfated glycosaminoglycan (GAG), cell-
surface-associated biopolymer and is the key component of tissue extracellular matrix …

An emerging body of evidence indicates that secreted proteoglycans act as signaling
molecules, in addition to their canonical function in maintaining and regulating the …

Hyaluronic acid (HA) is key to the stability of the internal environment of tissues. HA content
in tissues gradually decreases with age, causing age-related health problems. Exogenous …

Transition from homeostatic to reactive matrix remodeling is a fundamental adaptive tissue
response to injury, inflammatory disease, fibrosis, and cancer. Alterations in architecture …