Differentiation therapy holds promise as an alternative to cytotoxic drug therapy of cancer.
Among compounds under scrutiny for this purpose is the physiologically active form of …

Cellular stressors induce various outcomes including inhibition of cell proliferation and cell
death. Sodium salicylate (SA), a plant stress hormone, can suppress the proliferation or …

Abstract Analysis of the nonclassic actions of vitamin D 3 has highlighted a wide range of
target tissues for the hormone 1, 25-dihydroxyvitamin D 3 [1, 25 (OH) 2 D 3]. Systemic or …

We and others have demonstrated expression of the aldo-keto reductase AKR1C3 in
myeloid leukemia cell lines and that inhibitors of the enzyme, including nonsteroidal anti …

Nonsteroidal antiinflammatory agents (NSAIA) have been shown to exert potent
chemopreventive activity against colon, lung, and breast cancers. In this study, we show that …

Combined bezafibrate (BEZ) and medroxyprogesterone acetate (MPA) exert unexpected
antileukaemic activities against acute myeloid leukaemia (AML) and these activities are …

It is becoming increasingly well established that nonsteroidal anti-inflammatory drugs
(NSAID) protect against tumors of the gastrointestinal tract and that they may also protect …

Background The majority of acute myeloid leukaemia (AML) patients are over sixty years of
age. With current treatment regimens, survival rates amongst these, and also those younger …

Prostaglandin (PG) H2 (PGH2), formed from arachidonic acid, is an unstable intermediate
and is converted efficiently into more stable arachidonate metabolites (PGD2, PGE2, and …

A nonsteroidal anti-inflammatory drug (NSAID)—indomethacin (IN), was found to induce
apoptosis and inhibit proliferation of K562 cells and primary culture bone marrow cells from …