Transforming growth factor β (TGF-β) family members signal via heterotetrameric complexes
of type I and type II dual specificity kinase receptors. The activation and stability of the …

The actin motor protein non-muscle myosin II (NMII) acts as a master regulator of cell
morphology, with a role in several essential cellular processes, including cell migration and …

Chronic graft-versus-host disease (cGVHD) remains a major complication following
allogeneic bone marrow transplantation (BMT). The discovery of novel therapeutics is …

Dominant human genetic diseases that impair reproductive fitness and have high locus
heterogeneity constitute a problem for gene discovery because the usual criterion of finding …

TGF-β family signaling through Smads is conceptually a simple and linear signaling
pathway, driven by sequential phosphorylation, with type II receptors activating type I …

Alzheimer's disease (AD) is the leading cause of dementia and has no cure. Genetic, cell
biological, and biochemical studies suggest that reducing amyloid-β (Aβ) production may …

The emerging critical implications of Rho/Rho-kinase (ROCK) signaling in
neurodegenerative diseases, glaucoma, renoprotection, diabetes and cancer have sparked …

Transforming growth factor β (TGFβ) family members signal via heterotetrameric complexes
of type I (TβRI) and type II (TβRII) dual specificity kinase receptors. The availability of the …

Rho-associated kinase (ROCK) has an essential role in governing cell morphology and
motility, and increased ROCK activity contributes to cancer cell invasion and metastasis …

Transforming growth factor (TGF)-β-induced myofibroblast transformation and alterations in
mesenchymal-epithelial interactions contribute to chronic lung diseases such as chronic …