[HTML][HTML] Cas13d: a new molecular scissor for transcriptome engineering

R Gupta, A Ghosh, R Chakravarti, R Singh… - Frontiers in Cell and …, 2022 - frontiersin.org
The discovery of Clustered Regularly Interspaced Palindromic Repeats (CRISPR) and its
associated Cas endonucleases in bacterial and archaeal species allowed scientists to …

CRISPR detectives against SARS-CoV-2: a major setback against COVID-19 blowout

R Gupta, TA Kazi, D Dey, A Ghosh… - Applied microbiology …, 2021 - Springer
The emergence of SARS-CoV-2 has brought the world to a standstill, and till date, effective
treatments and diagnostics against this idiosyncratic pathogen are lacking. As compared to …

Computational analysis of cas proteins unlocks new potential in HIV-1 targeted gene therapy

W Dampier, R Berman, MR Nonnemacher… - Frontiers in genome …, 2024 - frontiersin.org
Introduction: The human immunodeficiency virus type 1 (HIV-1) pandemic has been slowed
with the advent of anti-retroviral therapy (ART). However, ART is not a cure and as such has …

A comprehensive review of the molecular and genetic mechanisms underlying gum and resin synthesis in Ferula species

MR Karimi, P Jariani, JL Yang, MR Naghavi - International Journal of …, 2024 - Elsevier
Ferula spp. are plants that produce oleo-gum-resins (OGRs), which are plant exudates with
various colors. These OGRs have various industrial applications in pharmacology …

[HTML][HTML] 2.5 A mechanistic study on the tolerance of PAM distal end mismatch by SpCas9

D Dey, R Chakravarti, O Bhattacharjee… - Journal of Biological …, 2024 - Elsevier
The therapeutic application of CRISPR-Cas9 is limited due to its off-target activity. To have a
better understanding of this off-target effect, we have focused on its mismatch-prone PAM …

Prospective Advances in Genome Editing Investigation

G Isola - Genome Editing in Cardiovascular and Metabolic …, 2022 - Springer
Genomic editing technology has been developed since 2010 through the use of some
techniques, such as the clustered regularly interspaced short palindromic repeat (CRISPR) …

Screening and Analysis of Potential Genes for DNA Damage Repair and Apoptotic Signal in iPSCs Based on CRISPR–Cas9 System

L Zhang, H Cui, M Zhu, K Zhao - Iranian Journal of Science and …, 2022 - Springer
Clustered regularly interspaced short palindromic repeats (CRISPR)-associated (Cas) 9
system is a site-specific gene editing technology developed in recent years, which can …